Leaving Neypotzli will cause any sulphurous essence in the player's inventory to be removed, accompanied by the message The resources from Neypotzli fizzle to dust as they are severed from its magic.. However, players can drop their essence before leaving and pick it up again after returning if they are fast enough.
It is always lost on death, even if reclaiming from the gravestone within the ruins.
On average, players killing sulphur nagua can expect to receive 31,250 Runecraft experience worth of sulphurous essence for every 1,000,000 combat experience gained, or 12.5 Runecraft experience per kill, assuming they pick up all sulphurous essence drops and lose none. With mid-game stats and utilising the boosts from moonlight potions, players killing sulphur nagua can expect to gain roughly 80,000 to 110,000 combat experience and 2,500 to 3,400 Runecraft experience per hour, making it a great alternative to other methods of melee training.