Disease

Disease is a status effect which can be caused by any monster found in the crypts of Jiggig: zogres, skogres, the zombie with the ruined backpack and Slash Bash as well as fever spiders and dire bats. It can also be caused by failing to pick the lock on an Ogre Coffin at Jiggig, while fletching scrapey bark from scrapey tree logs in Trouble Brewing (1/50 chance)^[1], or sailing through the fetid waters without an inoculation station onboard. Additionally, the bottle of zogre's sloppy kisses found while charting will disease as well as poison the player. Every 1.5 minutes, its strength will reduce by 1. It can be reapplied and will reset the disease amount to the max value applied by the source.

When a player has disease, shown by a yellow hitsplat (), one of the player's skills, excluding Hitpoints and Prayer, is reduced by the number on the hitsplat every 18 seconds; if the chosen skill drained is already at level 1, then it will instead reduce the player's Hitpoints,^[2] making death a possibility if the conditions are met. Stats are restored one level every minute meaning it can take a long time to naturally recover from reduced stats.

Wearing an inoculation bracelet provides protection against the effects of disease by preventing the reduction of skill levels and reduces the damage taken to 0, but it does not cure or immunise against disease.

Disease lasts different amounts of time depending on the source. Fever spiders inflict disease that takes 12 minutes to cure on its own. Disease from monsters and ogre coffins in Jiggig takes 15 minutes to cure, and disease from Slash Bash takes 22.5 minutes to cure. Skills gradually recover on their own, but for an instantaneous recovery, potions from Herblore can be used. Restore potions recover Combat skills except Prayer, while Super restore recovers all skills except Hitpoints.

The effects of disease can be countered with Relicym's balm. It will cure most disease in 3 doses (except for Slash Bash's, which will require 5 at its max strength). Instead of clicking the potion, a player may click the now-yellow hitpoints indicator to automatically drink their balm.

Sanfew serum will cure all disease (except for Slash Bash's) in one dose, along with giving a fifteen-minute immunity to disease (it also restores prayer points, cures poison, and gives a six-minute immunity to poison).

Bottle of elidinis's life water will cure all disease in one dose. It can only be consumed while in the boat and it is one time use.

The Cure Other, Cure Me, and Cure Group spells in the Lunar spellbook will not cure disease.

Disease can be cured by using a Pool of Refreshment in Ferox Enclave or an Ornate rejuvenation pool in a Player-owned house. However, the Elidinis Statuette does not cure disease.

Disease is also cured upon death and respawn, including through safe minigames such as the Emir's Arena. This may be easier (and cheaper) than using potions.

• An early design of this status effect proposed a variety of different diseases one could be infected with, coupled with a corresponding number of cures, though this complexity eventually led to the proposal being abandoned due to appearing unfun.^[3]
• According to slayer masters when asked for a tip with killing fever spiders, the type of disease the spiders carry is called the Spider Fever.^[4]
• The dire bat's use of disease was the first monster to do so since the fever spider was added to the game 7,547 days (20 years, 8 months) prior.

v t e Status effects
	Bleed Burn Corruption Disease Low Life (scrapped) Poison Skull Stun Venom

v t e Zogre Flesh Eaters
NPCs	Grish Zavistic Rarve Sithik Ints Bartender Brentle Vahn Slash Bash Zombie Ogre guard Zogre Skogre Uglug Nar Irwin Feaselbaum Johanhus Ulsbrecht
Items	Ruined backpack Dragon inn tankard Torn page Black prism Strange potion Cup of tea Unstrung comp bow Comp ogre bow Ogre arrow shaft Flighted ogre arrow Ogre gate key Ogre artefact Ogre coffin key Unfinished potion (Rogue's Purse) Relicym's Balm Books Portraiture Necromancy H.A.M. Sithik Portraits Good Bad Signed
Locations	Jiggig Jiggig Dungeon Yanille
Scenery	Broken lectern Cupboard Drawers Ogre Coffin Stand Wardrobe
Related	Quick guide Transcript Disease